Silditop is a medicinal drug, designed to cure erectile dysfunction in men using active substances, Sildenafil citrate Phosphodiesterase Type-5 (PDE-5) Inhibitor. It relaxes the blood vessels of the penis, increases blood supply, and allows men to acquire and maintain an erection.

Key Features

Different doses of Silditop

Features of Medication

• Medications like Silditop 50 mg, Silditop 100 mg contains Sildenafil Citrate as an active ingredient.
• These medications are being used to treat erectile dysfunction (ED).
• These medications have similar mechanism of action.
• These typically takes 30-60 minutes after oral administration.

How does it work?

Silditop smooths out blood vessels since Sildenafil Citrate blocks the phosphodiesterase type 5 enzyme that controls the blood flow. It increases blood flow to the penis, allowing for a natural reaction to sexual stimulation and causing men to be able to get and sustain erections.

• PDE5 inhibition: Silditop includes Sildenafil Citrate, which selectively inhibits phosphodiesterase type 5 (PDE5) enzyme.
• Increased cGMP levels: PDE5 inhibition results in elevated levels of cyclic guanosine monophosphate (cGMP) in the penis.
• Smooth muscle relaxation: cGMP induces smooth muscle relaxation, enabling the blood vessels to dilate.
• Increased blood flow: Vascular dilation increases blood flow to the penis, facilitating an erection.

Inhibition of PDE5 enzyme

Dosage

• Generally recommended dose is 50 mg, taken approximately 1 hour before sexual activity.
• Dose can be adjusted to 25 mg or 100 mg based on individual response and tolerance.

Benefit of using Silditop

• Silditop is to be taken for the treatment of Erectile dysfunction.
• Enhances erectile function, enabling men to achieve and maintain an erection.
• Can improve sexual confidence and overall quality of life.

Pharmacokinetics

• Absorption: Sildenafil Citrate is absorbed rapidly, with the maximum plasma concentrations attained within 60 mins.
• Distribution: It is widely distributed, approximately 105 L.
• Metabolism: It is metabolized in liver by CYP3A4, with a half-life of approximately 4 hours
• Excretion: The metabolites are excreted through feces (80%) and urine (13%).

Silditop interactions are classified into several categories:

• Drug interactions
• Food interactions
• Disease interactions

Drug Interaction

• Nitrates: Contradicted because of the potential for severe hypotension (e.g., nitroglycerin, isosorbide dinitrate)
• Alpha-blockers: Can cause symptomatic hypotension (e.g., doxazosin, terazosin)
• Antihypertensives: Can increase the hypotensive effects (e.g., beta-blockers, calcium channel blockers)
• Protease inhibitors: Can raise sildenafil levels (e.g., ritonavir, saquinavir)
• Antibiotics: Can raise sildenafil levels (e.g., erythromycin, clarithromycin)

Food Interaction

• Grapefruit juice: Can raise sildenafil levels
• Alcohol: Can enhance the chances of side effects such as dizziness and hypotension

Disease Interactions

• Cardiovascular Conditions: Patients with advanced heart disease, recent myocardial infarction, or uncontrolled hypertension must get in touch with their physician prior to using Silditop.
• Hepatic Impairment: Patients with liver failure might need dosage adjustment, as Silditop is metabolized through the liver.
• Renal Impairment: Patients with kidney dysfunction can also need dose adjustments since Silditop is eliminated by the kidneys.

Other Interactions

• Other ED medications: Must not be used with Silditop without the advice of a healthcare provider
• Certain medical conditions: Patients with heart disease, high blood pressure, or other disorders must consult a healthcare provider before using Silditop.

Pharmacokinetics

• Absorption: Sildenafil Citrate is absorbed quickly, with the maximum plasma concentrations attained within 30-120 minutes.
• Metabolism: Silditop is metabolized in the liver and has a half-life of about 3-4 hours.
• Excretion: The metabolites are excreted through feces and urine.

Side effects

• Headache
• Flushing
• Nasal Congestion
• Indigestion
• Dizziness

Precautions

• Silditop is to be administered cautiously in patients with cardiovascular conditions.
• Silditop is not to be administered to patients consuming nitrates.
• Patients with risk factors for priapism are to be administered Silditop cautiously.
• Usually administered an hour prior to expected sexual activity, with a maximum rate of once daily.
• Use is contraindicated in women, children, and adolescents because of the lack of research.

Conclusion

Silditop is a medically tested medication to treat erectile dysfunction and pulmonary arterial hypertension with efficacy and safety under medical guidance. It is necessary to consult a doctor prior to taking the medicine in order to get the best results with minimal risks.

FAQ’s

1) What is Silditop used for?

Silditop is a pharmaceutical drug, used to treat erectile dysfunction in men.

2) How does Silditop work?

Silditop relaxes blood vessels as Sildenafil Citrate inhibits the phosphodiesterase type 5 enzyme that regulates the blood flow.

3) What can be the common side effects

The common side effects can be Headache, Flushing, Nasal Congestion, Indigestion, Dizziness.

4) Is Silditop safe for everyone?

Yes, Silditop is generally considered to be safe for everyone but it is recommended to use after consulting medical profession or doctor.

References

https://pubchem.ncbi.nlm.nih.gov/compound/Sildenafil-Citrate

https://pubmed.ncbi.nlm.nih.gov/10400408/

https://pubmed.ncbi.nlm.nih.gov/18516312/