Vigora 100mg is a pharmaceutical drug used for the treatment of erectile dysfunction (ED) and pulmonary arterial hypertension (PAH) that has sildenafil citrate, a phosphodiesterase type 5 (PDE5) inhibitor, that attain and sustain an erection through improved blood flow to the penis. Vigora operates by relaxation of the smooth muscle present in the blood vessels, leading to improved blood flow.

Features

Product Details (Vigora 100 mg)

How does Vigora 100 mg work?

Sildenafil citrate is a cGMP-specific phosphodiesterase type 5 (PDE5) inhibitor. Sexual stimulation leads to the liberation of nitric oxide (NO) within the corpus cavernosum, which stimulates the guanylate cyclase enzyme to increase the levels of cGMP. Elevated cGMP causes relaxation of smooth muscles, promoting increased blood flow into penile tissues.

Prevention of the enzyme that breaks down cGMP by PDE5 allows Vigora to elevate cGMP levels, leading to vasodilation and facilitating sexual intercourse. This effect requires sexual stimulation and does not cause spontaneous erections.

Dosage of Vigora 100 mg

• Initial dose: 50 mg, take 1 hour before sexual activity.
• Adjusted dose: 25 mg to 100 mg based on individual response and tolerance.
• Maximum dosage should not exceed 100 mg in a 24-hour period.
• Take as needed but not more than once daily.

Side Effects of Vigora 100 mg

• Headache
• Flushing
• Dyspepsia
• Nasal Congestion
• Dizziness
• Visual disturbances
• Muscle pain
• Back pain
• Nausea
• Vomiting
• Sudden hearing loss
• Vision loss
• Priapism (prolonged erection)

Vigora 100 mg interactions are classified into several categories:

• Drug interactions
• Food interactions
• Disease interactions

Drug Interaction

• Nitrates: Contraindicated due to risk of severe hypotension (e.g., nitroglycerin, isosorbide dinitrate).
• Alpha-blockers: May cause symptomatic hypotension (e.g., doxazosin, terazosin).
• Antihypertensives: Can increase hypotensive effects (e.g., beta-blockers, calcium channel blockers).
• Protease inhibitors: Can raise sildenafil levels (e.g., ritonavir, saquinavir).
• Antibiotics: Can raise sildenafil levels (e.g., erythromycin, clarithromycin).

Food Interaction

• Grapefruit juice: Can increase sildenafil blood levels.
• Alcohol: Can increase side effects like dizziness and hypotension.

Other Interactions

• Other ED medications: Should not be combined without healthcare provider advice.
• Certain medical conditions: Patients with heart disease or hypertension should consult a doctor before use.

Disease Interactions

• Cardiovascular Conditions: Consult physician if advanced heart disease, recent MI, or uncontrolled hypertension.
• Hepatic Impairment: Dose adjustment may be necessary.
• Renal Impairment: Dose may require modification due to kidney elimination.

Pharmacokinetics

• Absorption: Fast, peak plasma concentration within 30-120 minutes.
• Bioavailability: Approximately 41%.
• Distribution: Volume of distribution ~105 liters.
• Metabolism: Primarily by liver cytochrome P450 enzymes.
• Excretion: Mostly fecal (~80%), half-life 3-5 hours.

Important Considerations

• Standard dose is 100 mg taken 1 hour before sexual activity, effective for 4-6 hours.
• Not recommended with nitrates, caution advised in cardiovascular or liver disease.

Clinical Trials

• Established efficacy and safety in treatment of ED and PAH.
• Shown to improve erectile function and alleviate PAH symptoms.

Efficacy

• Effectively enhances erectile function, increasing capacity to attain and sustain erection.
• Relaxes penile smooth muscles to increase blood flow, producing firm and lasting erection.

Precautions

• Patients with cardiovascular disease should consult doctor before use.
• Contraindicated with nitrates.
• Caution advised for patients on alpha-blockers.
• Not indicated for women, including during pregnancy or breastfeeding.

Conclusion

Vigora 100mg treats erectile dysfunction and pulmonary arterial hypertension by inhibiting PDE5, enhancing blood flow to the penis. Though generally well-tolerated, it may have side effects and drug interactions. Patients should consult doctors prior to use, especially with other medications or health conditions, to make informed treatment decisions.

FAQ’s

References

https://pubmed.ncbi.nlm.nih.gov/39078181/
https://pubmed.ncbi.nlm.nih.gov/12760589/
https://pubmed.ncbi.nlm.nih.gov/11219477/