Chlorocol 3 gm is a combination drug containing Chloramphenicol, a broad-spectrum antibiotic that inhibits bacterial protein synthesis, and Hydrocortisone, a corticosteroid that reduces inflammation and swelling in the eye.

Key Features

How it Works

Chloramphenicol binds to the bacterial 50S ribosomal subunit, inhibiting peptide bond formation and bacterial protein synthesis, resulting in bacteriostatic action that stops bacterial growth. Hydrocortisone reduces inflammation and swelling by suppressing immune responses.

• Chloramphenicol: Prevents bacterial protein synthesis, killing bacteria.
• Hydrocortisone: Reduces inflammation, swelling, and redness by inhibiting immune response.

Uses

• Bacterial conjunctivitis (eye inflammation)
• Keratitis (corneal inflammation)
• Uveitis (inflammation of the middle eye layer)

Dosage

Typically, 1-2 drops or a small amount of ointment in the infected eye 4-6 times daily. Duration generally 7-10 days, adjusted per severity and response.

Side Effects

• Mild burning or stinging sensation
• Blurred vision (temporary)
• Eye irritation including redness, itchiness, soreness
• Rare allergic reactions

Interactions

Chlorocol 3 gm may interact with:

• Bone marrow suppressants (risk blood disorders)
• Non-depolarizing muscle relaxants (risk muscle weakness)
• Potassium-depleting diuretics (risk low potassium)
• Voclosporin and butorphanol (may increase blood levels)
• Other eye drugs such as antivirals, antibiotics, corticosteroids

Pharmacokinetics

• Minimal systemic absorption from eye application.
• Localized distribution in the eye.
• Chloramphenicol metabolized by liver; hydrocortisone metabolized by liver and tissues.
• Excretion via urine (chloramphenicol) and urine/feces (hydrocortisone).

Efficacy

• Effective against bacterial eye infections like conjunctivitis, keratitis, and blepharitis.
• Clinical improvement often seen within a few days.
• Broad-spectrum antibiotic activity against many bacteria.

Safety

• Minor effects: stinging, burning, irritation, blurred vision.
• Rare severe effects: allergic reactions, aplastic anemia, bone marrow depression.
• Prolonged hydrocortisone use may cause glaucoma or worsen fungal/viral infections.

Precautions

• Caution in pregnancy and lactation due to limited data.
• Use caution in children and elderly.
• Avoid contact lenses during treatment.
• Monitor for infection worsening; inform doctor of allergy history.

Conclusion

Chlorocol 3 gm is an effective antimicrobial ointment for bacterial eye infections and inflammation. Follow prescribed use carefully to maximize benefits and minimize side effects.

FAQ’s

• What is Chlorocol 3 gm used for? Treatment of bacterial eye infections and reducing inflammation.
• Can I use Chlorocol 3 gm during pregnancy? Consult your physician; data is limited.
• Can I wear contact lenses during treatment? No, avoid contact lenses as they may worsen infection.
• How long does it take to work? Begins working immediately, full resolution may take several days.

References

• https://www.ncbi.nlm.nih.gov/books/NBK555966/
• https://pmc.ncbi.nlm.nih.gov/articles/PMC2814277/