Formonide 200 mcg Inhaler is a drug combination of Formoterol (6 mcg) and Budesonide (200 mcg) formulated to treat asthma and chronic obstructive pulmonary disease (COPD). It’s a corticosteroid and bronchodilator combination drug where Formoterol is a long-acting beta-2 agonist (LABA) medication and Budesonide is a corticosteroid medication and is prescribed for its anti-inflammatory properties.

 

Key Features

About
Drug Class	Corticosteroid + Beta2-Agonist
Subclass	Anti-asthmatic

Product Details
Composition	Active Ingredients: • Budesonide (200 mcg) • Formoterol (6 mcg)
Packaging Type	Inhaler
Pack Size	120 Metered Doses (MDI)
Dosage	As prescribed by your doctor (usually 2 puffs twice a day)
Therapeutic Class	Bronchodilator and Corticosteroid Combination
Action Class	Long-acting Beta2- Agonist (LABA) and Corticosteroid
Chemical Class	Formoterol and Budesonide
Manufacturer	Cipla
Shelf Life	2–3 Years from the Date of Manufacturing
Usages	Treatment of Asthma and Chronic Obstructive Pulmonary Disease (COPD)
Country of Origin	India
Storage	Store below 30°C in a cool and dry place, protected from direct sunlight, moisture, and heat.

 

How does Formonide 200 mcg work?

Formoterol (Long-acting beta-2 agonist)

• Smooth muscles relaxation in airways: Formoterol relaxes the airway smooth muscles, facilitating easy breathing.
• Increased airflow: By opening up airways, Formoterol enhances airflow through the lungs, removing wheezing, cough, and shortness of breath symptoms.

Budesonide (Corticosteroid)

• Decreases inflammation: Budesonide lowers airway inflammation and swelling, which minimizes symptoms and prevents exacerbations.
• Decreases mucus production: By lowering inflammation, Budesonide also reduces production of mucus, facilitating easier breathing.

Combination Therapy

Formoterol and Budesonide combination in Formonide acts synergistically to:

• Control symptoms: Formoterol’s bronchodilator properties and Budesonide’s anti-inflammatory properties control wheezing, cough, and breathlessness symptoms.
• Prevention of exacerbations: Through the alleviation of inflammation and enhancement of lung function, Formonide prevents exacerbations and enhances patients’ quality of life for respiratory diseases such as asthma and COPD.

 

Uses

• Asthma: Maintenance therapy for patients with asthma who need bronchodilator and corticosteroid treatment.
• Chronic obstructive pulmonary disease (COPD): Maintenance therapy for patients with COPD, such as chronic bronchitis and emphysema.

 

Dosage

Typically, 2 puffs twice a day. Dosage may be adjusted according to the condition of the patient and response to treatment.

 

Interactions

• Beta-blockers: Reduce effectiveness of Formonide.
• Ketoconazole: Increase level of Budesonide.
• Monoamine oxidase inhibitors (MAOIs): Increase cardiovascular risk. 

 

Pharmacokinetics

• Formoterol: Absorbed quickly, with maximum effects within 1-3 hours.
• Budesonide: Also absorbed quickly, with maximum effects within 1-2 hours.

 

Side Effects

• Coughing
• Sore throat
• Runny nose
• Headache
• Muscle cramps

Rare, but serious side effects are:

• Allergic reactions
• Increased heart rate
• Changes in blood pressure

 

How to use?

1. Shake the inhaler: Shake the inhaler thoroughly before each use.
2. Breathe out: Breathe slowly, away from the inhaler.
3. Inhale: Put the mouthpiece between your lips and breathe in slowly.
4. Activate the inhaler: Press the inhaler while inhaling to release the medicine.
5. Hold breath: Hold the breath from 5-10 seconds.
6. Rinse mouth: Rinse your mouth with water after use.

 

Important information

• Use Formonide according to your doctor’s prescription.
• Usually applied twice a day, in the morning and at night.
• Use the dosage and directions recommended.
• If you are unsure or have questions, talk to your doctor or pharmacist.

 

Clinical Trial

• VATHOS Trial: A 24-week randomised clinical trial comparing the efficacy and safety of budesonide and formoterol fumarate metered dose inhaler in adults and adolescents with poorly controlled asthma. The trial concluded that use of the two drugs was superior to either drug alone in improving lung function and relieving symptoms.
• SMART Therapy: A study has proved that the administration of a single inhaler for budesonide-formoterol as reliever and maintenance can reduce severe asthma exacerbations than traditional treatment.
• Pediatric Studies: There have also been studies on how effective budesonide-formoterol is in children with mild asthma, demonstrating its ability to stop asthma attacks but with a similar safety profile to salbutamol. 

 

Precautions

• Asthma exacerbations: Do not use with acute symptoms; instead, use a rescue inhaler.
• COPD exacerbations: Watch for worsening symptoms.
• Pregnancy and breastfeeding: Apply cautiously under medical surveillance.
• Cardiovascular conditions: Observe for elevated heart rate and blood pressure.

 

Conclusion

Formonide 6 MCG Inhaler is a combination drug having Formoterol and Budesonide, and it is applied to treat asthma and Chronic obstructive pulmonary disease (COPD). It’s a corticosteroid and bronchodilator combination drug where Formoterol is a long-acting beta-2 agonist (LABA) medication and Budesonide is a corticosteroid medication and is prescribed for its anti-inflammatory properties. It relaxes the muscles of airways and decreases inflammation. Use on a regular basis can control the condition, avoid exacerbations, and enhance lung function.

 

FAQ’s

1) What is Formonide 200 mcg used for?

Formonide Inhaler is a drug combination of Formoterol (6 mcg) and Budesonide (200 mcg) formulated to treat asthma and chronic obstructive pulmonary disease (COPD).

2) How does Formonide 200 mcg inhaler work?

Formoterol relaxes the airway smooth muscles, facilitating easy breathing, by widening the airways, Formoterol increases lung airflow, alleviating symptoms such as wheezing, cough, and breathlessness.

3) What can be the common side effects?

The common side effects can occur like coughing, sore throat, runny nose, headache, Muscle cramps.

4) Is Formonide safe for everyone?

Yes, it is safe for everyone, but it is recommended to use after consulting a physician or doctor.

5) How to use Formonide?

Formonide inhaler is used 1-2 puffs twice a day, by shaking the inhaler, breathing out, inhaling deeply while activating the inhaler.

 

References

https://pmc.ncbi.nlm.nih.gov/articles/PMC7708267/

https://pubchem.ncbi.nlm.nih.gov/compound/Formoterol