Ipravent Respules 2 ml is a nebuliser solution that helps open up the airways so you can breathe more easily. Ipravent Respules 2 ml are single-dose plastic ampoules (respules) filled with a clear solution. Each respule contains ipratropium bromide, an anticholinergic bronchodilator.Each 2 ml respule usually contains 500 micrograms (0.5 mg) of ipratropium bromide (as monohydrate), plus simple excipients such as sodium chloride and water for injection. The liquid is placed into a jet or ultrasonic nebuliser and inhaled as fine mist. It is used for short-term relief of bronchospasm in asthma and for maintenance or rescue therapy in chronic obstructive pulmonary disease (COPD).

Key Features

How does Ipravent Respules 2 ml work?

Ipratropium is an anticholinergic medicine. It blocks muscarinic receptors in the airways. This reduces vagal-mediated bronchoconstriction and dry-up of secretions. The net effect: airway smooth muscle relaxes and airways widen. The result is easier breathing and less wheeze. 

When used with a short-acting beta-agonist (for example salbutamol), ipratropium adds benefit because the two medicines work by different mechanisms — one blocks cholinergic constriction, the other stimulates beta receptors to relax airway muscle. Combination therapy is commonly used in acute exacerbations and in some long-term care plans. 

Why choose Ipravent Respules 2 ml?

• Easy to use with a nebuliser — helpful for children, elderly, or patients who cannot coordinate inhaler technique.
• Works quickly to reduce bronchospasm and relieve breathlessness.
• Can be used alone or added to beta-agonists in acute attacks.
• Single-dose respules cut down on contamination risk and ensure correct, measured dose. 

Main uses

Ipravent Respules 2 ml is commonly used for:

• Bronchospasm in COPD (maintenance and acute relief). 
• Acute severe asthma attacks, usually together with a beta-agonist. 
• Situations where nebuliser delivery is preferred (young children, ventilated patients, poor inhaler technique). 

This product is not a steroid and is not intended to replace inhaled corticosteroids when those are prescribed for long-term control.

Typical dosage

A common single-dose respule contains 500 µg of ipratropium in 2 ml. Typical regimens vary by age and condition, and your doctor will advise exact dosing. In acute care, ipratropium is often given every 6–8 hours or more frequently under supervision; in COPD it may be used regularly as maintenance. Always follow the prescribing instructions and the guidance of your healthcare team. 

How to use Ipravent Respules 2 ml (step-by-step)

1. Wash your hands.
2. Open the single-dose respule by twisting off the top (follow package instructions).
3. Pour the entire 2 ml into the nebuliser medicine cup.
4. Assemble the nebuliser and mouthpiece or mask.
5. Sit upright and switch the nebuliser on. Breathe normally through the mouthpiece until the mist stops (usually 5–10 minutes).
6. Turn off the machine and rinse the mouth (if directed). Clean the nebuliser parts per manufacturer instructions to avoid infection. 

Interactions and important warnings

• Hypersensitivity: Do not use it if you have a known allergy to ipratropium or atropine derivatives. 
• Other inhaled medicines: Ipratropium is often given with beta-agonists (salbutamol). This is safe and effective when used as directed. 
• Anticholinergic medicines: Using multiple anticholinergics together may increase side effects such as dry mouth, blurred vision, urinary retention. Tell your doctor about other medicines you take. 

If breathing worsens or you need more rescue medicine than usual, seek medical attention. Ipratropium is not a full substitute for corticosteroids when those are required to control inflammation.

Pharmacokinetics 

Ipratropium works mainly in the lungs after inhalation and has limited systemic absorption when used correctly. Whatever small amount reaches the circulation is poorly absorbed from the gut and is cleared largely by renal excretion. Because inhaled delivery keeps systemic exposure low, systemic anticholinergic effects are uncommon at normal doses. 

Common side effects

Most people tolerate ipratropium well. 

Common, usually mild effects include:

• Dry mouth or throat.
• Cough or throat irritation.
• Bitter taste.
• Headache.
• Rarely, blurred vision if the drug contacts the eye during nebulisation.

Serious side effects:

• Rash
• Swelling
•  severe breathing difficulty.

You should seek urgent care if you are experiencing these side effects.

Clinical evidence

Ipratropium bromide has decades of clinical use and is included in bronchodilator treatment guidelines for COPD and as an adjunct in acute severe asthma. Reviews and product monographs show benefit for bronchospasm relief and support combined use with short-acting beta-agonists for improved clinical response in certain acute settings. 

Precautions and special populations

• Children: Dosage and use in children require medical supervision. Nebuliser delivery can be preferable for younger children. 
• Pregnancy and breastfeeding: Use only if clearly needed and under medical advice. The inhaled route limits systemic exposure, but a doctor will weigh risks and benefits. 
• Elderly: Monitor for anticholinergic effects such as urinary retention or confusion in frail, elderly patients. 

Storage and handling

Keep the respules in their sealed pouch until use. Store at room temperature and protect from light as instructed on the package. Use each single-dose respule immediately after opening and discard any unused portion. Follow local disposal rules for medical waste. 

Conclusion

Ipravent Respules 2 ml is a practical, effective nebuliser solution containing ipratropium bromide. It works by blocking muscarinic receptors to relax and widen the airways. It is useful in COPD and as an adjunct in acute asthma care, especially where nebuliser treatment is preferred or needed. Like all medicines, it should be used exactly as prescribed. If you have doubts about dosing, interactions, or side effects, consult your healthcare provider. 

Frequently Asked Questions (FAQ’s)

Q1. What is Ipravent Respules 2 ml used for?

It treats bronchospasm in COPD and can be used with a beta-agonist in acute asthma attacks. It is delivered via nebuliser. 

Q2. How quickly does Ipravent Respules 2 ml work?

Many patients feel improvement within minutes after nebulisation, though full effect depends on the severity of the obstruction. 

Q3. Can I use Ipravent Respules 2 ml with salbutamol?

Yes, Ipratropium plus salbutamol is a common and effective combination for acute bronchospasm. Follow medical guidance for dosing. 

Q4. Are there side effects to watch for?

Common effects are dry mouth, cough, bitter taste, and throat irritation. Rarely, systemic anticholinergic effects occur. Stop and seek care for allergic symptoms. 

Q5. How should I store Ipravent Respules 2 ml?

Keep respules in the sealed pouch until use. Store at room temperature, away from direct heat and light, and use immediately after opening. 

References

https://www.ncbi.nlm.nih.gov/books/NBK544261/

https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=db8095db-d1fd-4099-9fb1-d1ad4e284976

https://pubmed.ncbi.nlm.nih.gov/6448137/

https://pmc.ncbi.nlm.nih.gov/articles/PMC7901745/