Orcibest 10 mg is a bronchodilator that contains Orciprenaline, a synthetic amine with bronchodilator properties. It is used in the treatment of respiratory conditions such as asthma and chronic obstructive pulmonary disease by relaxing the airway muscles and improving airflow.

Key Features

How does Orcibest 10 mg work?

Orcibest 10 mg works by stimulation of β2-adrenergic receptors in the lungs, uterus, and vasculature supplying skeletal muscles. Stimulation of the enzyme adenylate cyclase, responsible for the synthesis of the second messenger cAMP, promotes the relaxation of smooth airway muscles and consequently leads to dilation of the airways with improved airflow.

• Relaxing Airway Muscles: Orcibest 10 mg tablet relaxes the smooth muscles in the airways, thereby facilitating easier airflow and breathing.
• Increased cAMP: The drug activates the enzyme adenylate cyclase, which results in increased intracellular levels of cAMP. This nucleotide induces the relaxation of bronchial smooth muscles and decreases the release of inflammatory mediators from mast cells.

Uses

Indication Orcibest 10mg is used to treat:

• Asthma: A chronic respiratory condition with inflammation, airway constriction, and excessive mucus production.
• Chronic Obstructive Pulmonary Disease (COPD): This is a group of lung diseases that block airflow and make it hard to breathe.
• Dosage
• The dose of Orcibest 10 mg is based on the patient’s medical condition, age, and response to therapy. It is usually taken by mouth three times a day with or without food. It is very crucial that you follow your doctor’s dosage instructions and do not take more than the prescribed dose.

Side Effects

Common side effects associated with Orcibest 10 mg include:

• Apprehension
• Dizziness
• Headache
• Racing pulse
• Tremors
• Nausea and vomiting
• Diarrhea 

Interactions

 Orcibest 10 mg may interact with:

• Beta-blockers: such as propranolol, which may reduce its efficacy
• Monoamine oxidase inhibitors (MAOIs): Examples are phenelzine, which may increase the risk of adverse effects.
• Diuretics: examples include furosemide, which can increase the risk for hypokalaemia (low levels of potassium).

 Pharmacokinetics

The pharmacokinetics of Orcibest 10 mg includes:

• Absorption: rapid absorption after oral administration.
• Peak effect: within 30-45 minutes.
• Duration of action: up to 2-6 hours.

Precautions

Precautions to be taken while on Orcibest 10 mg:

• Cardiovascular disease: Orcibest 10 mg may worsen pre-existing heart conditions
• Diabetes: Orcibest 10 mg may affect blood sugar control
• Hyperthyroidism: Orcibest 10 mg can worsen the symptoms of an overactive thyroid gland.
• Pregnancy and lactation: Orcibest 10 mg should not be used during pregnancy and lactation unless specifically indicated by the doctor.

Safety

The safety and efficacy of Orcibest 10 mg-Orciprenaline have been established in various clinical indications in the treatment of respiratory ailments such as asthma and COPD.

Efficacy

• Bronchodilation: Orcibest 10 mg relaxes bronchial smooth muscles effectively, thereby increasing airflow and relieving bronchospasm associated with asthma and COPD.
• Symptom Relief: Clinical trials have demonstrated the efficacy of Orciprenaline in quickly alleviating symptoms such as wheezing, shortness of breath, and coughing.
• Quick Onset: The drug has a relatively fast onset of action; thus, it is suitable for acute relief of bronchospasm.

Conclusion

Orcibest 10 mg is a medicament from the class of bronchodilators, which effectively treats respiratory conditions like asthma and COPD. Although it might have side effects and interactions with other drugs, its full benefits can be assured by proper dosage administration and observing the precautions.

FAQs

• What for Orcibest 10 mg used for?

Orcibest 10 mg used to treat respiratory conditions such as asthma and chronic obstructive pulmonary disease.

• How does Orcibest 10 mg work?

Orcibest 10 mg works by stimulation of β2-adrenergic receptors in the lungs, uterus, and vasculature supplying skeletal muscles.

• Is Orcibest 10 mg addictive?

No, Orcibest 10 mg is not addictive.

• Can Orcibest 10 mg be taken with food?

Yes, Orcibest 10 mg can be taken with or without food.

• What if I miss a dose?

Take the missed dose as soon as possible, but skip it if it’s almost time for your next dose.

• Can I drink alcohol with Orcibest 10 mg?

It is better to avoid alcohol while taking Orcibest 10 mg.

• Is Orcibest 10 mg safe for children?

Orcibest 10 mg should be used with caution in children, and only under the guidance of a doctor.

References

https://pmc.ncbi.nlm.nih.gov/articles/PMC1647782/

https://pubmed.ncbi.nlm.nih.gov/4976173/